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6 Future perspectives Metabolomics is to become an important tool in research related to the investigation of drug-induced hepatotoxicity, allowing researchers to assess the deleterious effects of xenobiotics by identifying changes in metabolite levels that uncover the toxic mechanisms at play, the identification of biomarkers of interest suitable for clinical diagnosis and facilitating the development of predictive models

(5) Immunometabolic Reprogramming: Polarization of ATMs toward M2 phenotypes with concurrent suppression of NF-B/STAT3 inflammatory cascades

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In particular, Ras mutations induce dysregulated cell division within thyroid follicular cells, leading to hyperplastic thyroid lesions including nodules (Peterson 2014)