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The rate of decoding these synonymous codons are biased, which is evident by the disproportionate representation in certain codons over other types in the transcriptome [28]

J Mater Chem B 29:45614567

However, it's worth noting that the activation of PI3K/mTOR and CDK signaling pathways is also observed in normal tissues, which may cause adverse effects and reduce the bioavailability of molecular inhibitors [258, 259]