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Motzer RJ, Escudier B, Powles T, Scheffold C, Choueiri TK

Most CGI promoters have heterogeneous transcription start sites and lack TATA boxes, so transcription factors with CpG in their recognition sites, such as SP1, can help recruit TATA-binding protein to promoters without TATA boxes

Always match therapy type to the individuals actual profile, not to diagnostic labels or assumptions

Here we find increased proportion of pro-inflammatory and mesenchymal fibroblast subpopulations and senescent fibroblasts, and enhanced expression of senescence-associated secretory phenotype genes using single-cell RNA sequencing analysis, as well as elevated p16 protein and more -galactosidase-positive cells in keloids