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doi: 10.1210/jc.80.4.1407

So I thought I'd answer 10 of the most frequently asked in this article

Of note, on contrast to enzymes, enantioselective introduction of a proton to transient enediol intermediate via synthetic route might be extremely challenging to control it in terms of enantioselectivity due to the small size of the proton 3,7,8,9,10,11