In addition to hallmark motor symptoms, it manifests a wide range of nonmotor complications, including cognitive decline, neuropsychiatric symptoms, autonomic dysfunction, and comorbid metabolic and infectious diseases
This evidence reflects the role of the mitochondria as key targets for promoting apoptosis and also provides evidence for the role of other organelles like acidocalcisome as targets to store divalent Ca 2+ and heavy cations, Fe 2+ and Zn 2+ , which could be able to capture quinoline compounds via coordination binding
Ferroptosis in heart transplantation For patients suffering from severe coronary artery disease and advanced congestive heart failure, heart transplantation stands as the most effective treatment option
To overcome these problems, various halogenated derivatives (e.g., chlorinated or boronated PBN), alkylated derivatives having a lipophilic tail (e.g., those with dodecyl chains), bifunctional derivatives (e.g., GS-PBN, Mito-DEPMPO, 5-ChEPMPO, DECPO, and 4-HMDEPMPO), conjugates with drugs or targeting molecules (such as PEG or heparin, that both can cross the BBB), dimers, and cyclodextrin polymers have been developed in the last few years (Wang et al., 2021
