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Because its oral absorption is affected by digestive enzymes, high-quality supplements often use the reduced form (GSH) or combine it with vitamin C to improve bioavailability

Since the raison detre for a micronutrient prescription is to boost the supply of CH 3 and SH moieties (Section 3), the inefficacy of the micronutrient curcumin (despite curbing lipid peroxidaton and being a potent inhibitor of mast cells) and allopurinol (inhibitor of xanthine oxidase) in clinical trials indicates that these substances do not achieve the goal: of note, curcumin did not increase GSH in erythrocytes

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Scaglia F, Sutton VR, Bodamer OA, Vogel H, Shapira SK, Naviaux RK, Vladutiu GD