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Vitamin and Cofactor Chemistry Glutathione interacts with other redox systems, including pathways involving vitamin C, thioredoxin and NADPH

These include positive regulators, such as ferredoxin 1 (FDX1) , lipoic acid synthase (LIAS) , lipotransferase 1 (LIPT1) , dihydrolipoamide dehydrogenase (DLD) , thiolipoamide S-acetyltransferase (DLAT) , pyruvate dehydrogenase E1 subunit 1 (PDHA1) , and pyruvate dehydrogenase E1 subunit (PDHB) , as well as negative regulators, like metal-responsive transcription factor-1 (MTF1) , glutaminase (GLS) , and cyclin-dependent kinase inhibitor 2 A (CDKN2A) [25]

Insulin resistance, a hallmark feature of metabolic syndrome and NAFLD, is another critical target modulated by polyphenols

Note that in many cases the density barrier enrichment of DCs is followed by further purification using antibody-bound beads 2