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While ROS generation is modest during the ischemic phase due to oxygen deprivation (Sen et al., 2024), a substantial and rapid burst occurs upon the sudden reintroduction of oxygen during reperfusion (Xiang et al., 2021

Surprisingly, resistance of A431-B1 cells to APDTC and COTI-2 was not abrogated in the presence of tariquidar, which fully abolished resistance to doxorubicin