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In juvenile grass carp ( Ctenopharyngodon idella ), demonstrated that fish fed histidine-deficient diets exhibited increased erythrocyte osmotic fragility, reduced antioxidant enzyme activities, and lower hypoxia tolerance, suggesting that histidine contributes to maintaining cellular membrane integrity and enhancing resistance to oxidative damage under stressful conditions

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Signals are then transferred to inner compartment via receptors located on the plasma membrane initiating a signal transduction pathway to readjust cell metabolism to the new conditions

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