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Soares et al., 2023): vascular response

The effects of S100A7 on NF-B and phosphor-Akt pathway are dependent on the Jab1-binding domain and the interaction with Jab1 because mutation at the Jab1 binding domain of S100A7 does not stimulate phosphor-Akt (88)

heterocycle or heterocyclic ring, as used herein except where noted, represents a stable 5- to 7-membered monocyclic-, or stable 7- to 11-membered bicyclic heterocyclic ring system, any ring of which may be saturated or unsaturated, and which consists of carbon atoms and from one to three heteroatoms selected from the group consisting of N, O and S, and wherein the nitrogen and sulfur heteroatoms may optionally be oxidized, and the nitrogen heteroatom may optionally be quaternized, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring

These foci likely reflect R-loops persisting from S-phase because neither oncogene induced TRCs in G2 cells, as revealed by QIBC analysis of PCNA/RNAPII PLA foci (Supplementary Fig