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Glutathione is naturally present in the placenta, where it acts as a primary defense mechanism

Phys Rev B 81, 012102

10.1021/acs.jmedchem.7b00389 98 NowotnyK.JungT.HhnA.WeberD.GruneT

Upon activation, calcineurin dephosphorylates and stimulates TFEB, which in turn translocates into the nucleus where it binds to the coordinated lysosomal expression and regulation (CLEAR) sequence to upregulate expression of several genes involved in the autophagic pathway (Tong and Song, 2015