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It has been shown that thiamine can relieve pain by inhibiting the activity of thalamic and spinal neurons, affecting the effectiveness of the neurotransmitters noradrenaline and 5-hydroxytryptamine [8082]

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The activity of Nrf2 is repressed by a redox-sensitive Kelch-like ECH-associated protein (Keap1), which acts as a substrate adaptor protein that interacts with Nrf2 in the cytoplasm, promoting its polyubiquitination by the Cullin 3 (Cul3) E3 ubiquitin ligase (McMahon et al

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