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Safety and Tolerability Safety is where the two are least symmetric, and it is often oversimplified

Activation of AMPK in neurons also promotes mitochondrial biogenesis and oxidative glucose metabolism by increasing the expression of the master mitochondrial regulators, peroxisome proliferator-activated receptor gamma coactivator-1 ( PGC-1 ) and mitochondrial transcription factor A ( mtTFA ) [120]

Specifically, CAR T cells in the day 28 BM of LTR had significantly higher expression of mTOR, pS6, pAKT (mTOR and pAKT pathways) and the metabolic sensor AMPK, as well as significant increases in the fermentative glycolysis enzyme LDHA, the endogenous fatty acid metabolism enzymes SCD1, LAL, and CD45RA, suggesting an effector immunometabolic phenotype