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2 mM dl-propargylglycine (PPG, SigmaAldrich), 0.2 mM l-homocysteine (Hcy, SigmaAldrich), or 0.5 mM l-methionine (Met, Research Products International, Inc) was added as indicated

70 Moreover, in tissues of PDA patients, lactylation of TFEB at lysine 91 has been identified, which prevents its ubiquitination and proteasome degradation by hindering its interaction with the E3 ubiquitin ligase WWP2, enhancing TFEB activity and autophagy flux, which promotes pancreatic cancer progression

Br J Clin Pharmacol 66(4):444450 Cavallini G et al (2004) Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging

(64) directly extracted polymorphonuclear neutrophils (PMNs) from the peripheral blood of GA patients and added MSU crystals for modeling and research