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Consequently, for less potent payloads, higher DAR values may be necessary to achieve sufficient cell-killing effects

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The industry generally believed that despite the lack of a complete understanding of the precise mechanisms, the main mechanisms of action involved the modulation of the autonomic nervous system (ANS), promotion of angiogenesis, enhancement of nitric oxide (NO) synthesis, and exhibition of antioxidant and anti-inflammatory properties (Soltani et al., 2023)

Genetic deletion or pharmacological inhibition of Epac1 blocked high glucose-induced mitochondrial dysfunction and protected against pericyte loss (109)