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Using sdAbs and scaffold proteins as radiopharmaceuticals has shown significant advantages, though bone marrow and kidney toxicity remain concerns

Colostrum has mainly a physiological purposetransitioning the immune, gastrointestinal system, and metabolism to life outside the uterusand less a nutritive purpose

have attempted to generate recombinant chimeric mouse IgG2a heavy chain antibodies, grouped into five distinct families, that bind non-overlapping epitopes of CD38 [91]

This clearly implies that, although several in vitro tests for genotoxicity assessment are available at different stages of development and acceptance, they cannot be considered to fully replace animal tests needed to evaluate the safety of substances (see Adler et al., 2011)