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Exposure to pristane causes lupus-like disease that is characterized by interferon(IFN)-I-dependent autoantibody production, inflammatory cytokines and renal diseases in susceptible mouse models ( Induction of pristane-induced autoantibodies has been shown to be dependent on the inflammatory cytokines as protective effects on nephritis and autoantibodies were observed in INF- / , IL-6 / , IL-12 / , and IL-17 / mice ( Silica Among the environmental and occupational agents associated with immune dysregulation, silica is considered a notable risk factor due to its widespread exposure

In another work on the Inuit population of Nunavik, children exposed to toxic doses of Hg influenced heart rate variability (HRV), while in adults it also influenced the BP component (99)

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