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Biochem Biophys Res Commun (2004) 322:111122

Beware that cooking and processing may reduce thiamine levels in food

According to a recent review (297), clinical limitations often include heterogeneity of probiotic strains, large dose variability, and limited follow-up

Finally, the functional redundancy or compensation between iron metabolic regulators in ferroptosis (e.g., whether inhibition of TFR1 can be rescued by enhanced ferritinophagy) has not been rigorously evaluated, which is essential for designing robust therapeutic strategies targeting iron-dependent ferroptosis