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Absorption of Vitamin B12 in food requires a substance from our stomachs called intrinsic factor, the production of which decreases with age

Consistent with our initial findings in the siRNA screening, the knockdown of DYNLRB1 and GSK3B by different knockdown paradigms (i.e., esiRNA and siPOOL siRNA) protected human dopaminergic neuron-like cells (LUHMES cells) from aSyn-induced toxicity