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Second, Bmal1 knockdown alters the secretion of factors that likely enhance astrocyte function, promoting AQP4 polarization and improving glymphatic flow, which facilitates A transport to the CSF for clearance

10.1016/j.addr.2014.05.008 40 DasenbrookE

Therefore, while our data demonstrate robust adipose tissue remodeling following Retatrutide treatment, they do not by themselves establish direct cell-autonomous effects on adipocytes or adipose-resident immune cells