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Only one of these studies was an RCT (Summers et al ., Reference Summers, Elliott, Urban, Thompson and Weinstock2005 b ), and as such had control for comparison, but all the studies showed a statistically significant improvement (where statistical analysis was available) (Summers et al ., Reference Summers, Elliott, Qadir, Urban, Thompson and Weinstock2003, Reference Summers, Elliott, Urban, Thompson and Weinstock2005 a , Reference Summers, Elliott, Urban, Thompson and Weinstock2005 b

trimethoprim also distributes to bronchial secretion, and both pass the placental barrier and are excreted in human milk