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The basic understanding of T cell-mediated MS onset and progression has recently been modified to take into account the crucial bilateral communications between multiple immune cells such as peripheral myeloid cells, B and T cells as well as the native CNS cells like microglia and astrocytes [33]

Moreover, ROS production induced by DMF, FG4592, or DMF and FG4592 cotreatment was attenuated in low-iron medium compared with control (Figure 5H)

In these studies, the beneficial effect of riboflavin supplementation (Reference Yu, Morimoto and Yu32,Reference Jiang, Chen and Liu33,Reference Peraza, Guzmn and Brizuela45) and the deleterious effect of its deficiency (Reference Jiang, Chen and Liu33,Reference Chen, Feng and Jiang35) on ROS levels in different tissues have been indicated

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