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Treating and preventing sleep problems effectively requires an understanding of the underlying causes

This is clearly demonstrated by experiments in which the administration of the neurotoxin MPTP, which blocks Complex I of the mitochondrial electron transport chain, induces characteristic features of PD in mice [56, 57]

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Regulation of lipidinduced macrophage polarization through modulating peroxisome proliferatoractivated receptorgamma activity affects hepatic lipid metabolism via a Tolllike receptor 4/NFB signaling pathway