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Research (168) indicates that the Fe 2+ directly induced by myoglobin metabolism may lead to lipid peroxidation in proximal tubule epithelial cells, which could be an important pathogenic mechanism of rhabdomyolysis-induced acute AKI

In the hours to days following the initial injury, neuronal and glial dysfunction, metabolic changes, neuroinflammation, and the release of signaling and inflammatory molecules from neurons, glial cells, and immune cells occur

Fiorenzano, A., Sozzi, E., Birtele, M., Kajtez, J., Giacomoni, J., Nilsson, F., et al

SPT6 binds to the phosphorylated C-terminal-domain linker and opens the RNA clamp formed by DSIF