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Allosteric inhibition of phosphofructokinase-1 by citrate forms the basis of the Pasteur effect, the absence of which is critical for understanding the Warburg effect, i.e., aerobic glycolysis, a general feature of not just tumor cells 99 , but also healthy proliferating cells 100 such as lymphocytes and stem cells 101,102

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The conditions that have been associated with glutathione deficiency include the following: Neurodegenerative diseases such as Alzheimers, Parkinsons and Huntingtons disease and ALS Pulmonary diseases such as COPD, asthma, and acute respiratory distress syndrome Immune system disorders Cardiovascular diseases such as high blood pressure, elevated cholesterol, and heart attacks Chronic age-related disorders such as cataracts, macular degeneration, hearing impairment, and glaucoma Liver disease Cystic fibrosis Aging processes (Pizzorno, 2014)

In the setting of CAP, vitamin E's anti-inflammatory characteristics may aid in reducing lung inflammation and thereby improve patient outcomes