acetaminophen overdose napqi glutathione mechanism authoritative source What is the antidote of choice for poisoning? N-acetylcysteine (NAC) Answer in the story NAPQI - Wikipedia
NAPQI Wikipedia Acetaminophen metabolism. Acetaminophen is metabolized primarily by sulfation and glucuronidation. However, it can also be oxidized by CYPs to form NAPQI. NAPQI can then interact with cellular macromolecules, resulting in toxicity, or it can be detoxified Acetaminophen Anesthesia Key PGC 1 Induces Susceptibility To Acetaminophen Driven Acute Liver Failure Scientific Reports
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