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Acknowledgements We thank the participants for their kind cooperation, and we are grateful to Dr Cristopher Record for his clinical involvement

Dark under-eye circles can be caused by various factors, including genetics, thinning skin due to aging, lack of sleep, dehydration, allergies, pigmentation irregularities, and lifestyle habits like smoking or excessive alcohol consumption

Additionally, BPC-157 therapy reduces the swelling in the injury area

(2024, CNS Neuroscience & Therapeutics ) confirmed ARA-290 provided neuroprotective effects in a mouse MCAO (middle cerebral artery occlusion) model comparable to full-length EPO, significantly reducing neuronal apoptosis and inflammatory cytokines, confirmed to act via CR without stimulating erythropoiesis Blood-brain barrier (BBB) penetration confirmed in pre-clinical studies