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This process ultimately results in acute arthritis flares ( Acting as a DAMP, MSU crystals are detected by innate immune cells through pattern recognition receptors (PRRs), including members of the Toll-like receptor (TLR) family, and thereby directly initiating an immune response ( Phagocytosed MSU crystals induce intracellular stress signals, including lysosomal rupture, potassium ion (K + ) efflux, and mitochondrial ROS generation

This increased circulation can enhance ovarian function and support healthy ovulation

It also promotes angiogenesis, or the formation of new blood vessels, allowing for increased oxygenation to the tissues