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The reaction rate is influenced by the nucleophilicity of the thiolate, resulting in the enhanced capacity of NAC for reducing disulfide bonds compared to cysteine and GSH (Noszl et al., 2000)

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HO-1 has antioxidant properties in addition to the anti-inflammatory actions in different tissues [3335], derivatives of the reduced metabolites of the free heme groups, mainly by pattern recognition receptors (PRR) such as TLR-4 [36]

10.1038/s41563-018-0180-8 23 BurkeJ