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Thus, the transition from crystal deposition to acute inflammation can be conceptualized as a two-hit process: First hit: MSU crystal deposition on cartilage surfaces activates synovial fibroblasts to release CCL2/MCP-1, recruiting monocytes and establishing subclinical inflammation

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Nasal Polyposis with Thick Mucus or Biofilm NAC may help in polyp-prone patients to reduce mucus plugging and microbial load Typically combined with Budesonide or other anti-inflammatory agents What Are The Common Combinations of N-Acetylcysteine