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Pathophysiology of Disk-Related Sciatica

Cellular signaling work has examined its effects on glucose uptake, fatty acid oxidation, and insulin sensitivity across multiple tissue types, particularly skeletal muscle and adipose tissue

Kim M, Jee SC, Kim KS, Kim HS, Yu KN, Sung JS

Islet amyloid, formed by the aggregation of the beta cell peptide hormone islet amyloid polypeptide (IAPP), is a strong proinflammatory stimulus, triggering islet inflammation and contributing to beta cell dysfunction [11,12,13,14,15]