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The primary findings were an increase in the incidence of subcutaneous fibrosarcomas in high-dose male rats receiving valproate and a dose-related trend for benign pulmonary adenomas in male mice receiving valproate

Bassino, E., Gasparri, F

Biochem J 334 (Part 3): 617623

107 In response to various stimulations, PDK1 can activate phosphoinositide-3 kinase (PI3K) and then Akt, playing pivotal roles in energy metabolism, cell proliferation and migration