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In preclinical models, leaky tumor vessels and impaired lymphatic drainage can support higher local retention of long-circulating particles

Besides ebselen, the CC 50 of all tested compounds exceeded 50 M, indicating their generally low cytotoxicity

In the context of ARDS, ferroptosis contributes to the destruction of alveolar and endothelial cells, leading to increased vascular permeability, pulmonary edema, and impaired gas exchange

7 Limitations and Potential Risks Despite promising results, certain limitations and risks must be considered: Limited Sample Sizes and Durations: Many clinical studies on AOD 9604 have relatively small sample sizes and short durations, which may affect the generalizability of their findings