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Although strategies such as continuous-flow synthesis show promise, further systematic validation across multiple CQD systems and production scales is required to establish their general applicability

Patients who fail to obtained symptomatic relief with medical therapy or who developed long term complications from reflux should consider surgical intervention

Beyond B12, patients on semaglutide should consider monitoring iron, folate, calcium, and vitamin D levels, as reduced appetite may lead to lower overall nutrient intake

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