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In the lumbar region of human spine, the size of vertebrae is 710 mm in thickness and 4 cm in diameter (Twomey and Taylor, 1987

Their activation occurs through different pathways including phosphorylation of cytosolic regulatory subunits by protein kinase C, protein kinase A, phosphatidylinositol-3-kinase (PI3K), mitogen-activated protein kinases (MAPK), and non-receptor associated protein kinases, such as Janus kinase (JAK) and Src, the non-receptor tyrosine kinases (Manea et al., 2015)

When we computationally isolated the glioma cells and performed unsupervised clustering, we identified a minute but discrete cluster consistent with an astrocyte-like population, which was consistently represented across replicates based on GSEA of the various glioma cell state signatures (Appendix Fig