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La cascada proteoltica, que conduce al refuerzo del tapn plaquetario, se produce por una serie de reacciones, en las que un zimgeno en circulacin (precursor enzimtico inactivo) de una serina proteasa y su glicoprotena cofactora se activan para volverse componentes activos que a continuacin catalizan la siguiente reaccin en la cascada, dando como resultado en ltima instancia fibrina reticulada

Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice

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In bacterial meningitis, changes in PCs were more strongly correlated with local CNS disease than systemic inflammation, which suggests dysfunction of the blood-CSF barrier leading to cell death