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Cutting-edge directions and future prospects of neuronal metabolism research Looking ahead, integrating multi-omics approaches such as 4-dimensional fast data-independent acquisition (4D-FastDIA) quantitative proteomics and targeted metabolomics [e.g., dissecting how Danggui-Shaoyao-San regulates the glycogen synthase kinase 3 beta (GSK3)/PGC1 signaling pathway to improve brain glucose uptake and mitochondrial complex function in AD models (Wu et al., 2024)] with computational modeling is unraveling systematic regulatory networks in neuronal energy metabolism, pinpointing critical nodes like pyruvate dehydrogenase complex phosphorylation and dynamic MCT2 transporter expression (Brown and Ransom, 2007)

(2017) 78:e766e73

doi: 10.1016/j.molcel.2015.06.011 18 Garcia-GonzaloF

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