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Reactions that warrant attention include persistent swelling or redness lasting more than 24 hours, significant pain beyond the initial injection moment, the development of hard nodules that do not resolve within a day or two, fever or systemic symptoms following injection, or any sign of infection at the injection site including warmth, pus, or spreading redness

All trials employed randomized, double-blind, placebo-controlled designs, representing the gold standard for clinical research

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