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Moreover, seminal plasma helps protect and mature sperm, since mature spermatozoa are transcriptionally and translationally inactive, with a condensed nucleus (DNA/chromatin tightly packed and protected with protamines and disulfide bonds) and with reduced cytoplasm and no ribosome content (29) (Figure 1)

Novel approaches such as transporter tandems might also help to assess the influence of gene polymorphisms on OCT/Ns functional activity and to determine their (patho)physiological consequences in the lung [45] (see Section 3.5 for further details)

Ignoring reconstitution accuracy Imprecise measurement during reconstitution creates concentration errors affecting every subsequent dose