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The problem with grouping people in this way, however, is that there may be selection biases differences between the groups which could influence the results of the study such as personality types of people who are keen to participate in interventions versus those who are not, or unintended differences in access to the intervention due to location

Clinical trials face challenges in selecting the best target population, patient stratification, accurate clinical diagnosis, and distinguishing between diseasemodifying effects and symptomatic effects

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