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Fecal transplantation experiments revealed that when mice were infected with stool from NAFLD patients they developed hypertriglyceridemia in the liver and developed liver steatosis and change of gut microbes are implicated in NAFLD (Hoyles et al., 2018), the end products of saccharolytic and proteolytic fermentation by the gut microbiota (GM) are believed to influence the gut-liver axis and can directly impact the pathogenesis of non-alcoholic fatty liver disease (NAFLD)

doi: 10.1080/15548627.2020.1715047 114 YuXLiCSongHWangXGuoYCuiLet al

However, the delivery of NBTs is highly challenging in terms of target specificity (intracellular delivery), mononuclear phagocyte system uptake, stability and biodistribution

Indeed, dimethyl fumarate can rescue antioxidant enzyme expression as well as increase neuritic arborization and complexity in hiPSC-derived dopamine neurons harboring the A53T aSyn mutation 128