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Immediate medical attention is essential if any signs of paracetamol toxicity or liver deterioration develop, including: Nausea, vomiting, or loss of appetite persisting beyond 24 hours Abdominal pain, particularly in the upper right quadrant Yellowing of the skin or whites of the eyes (jaundice) Dark urine or pale stools Unusual bruising or bleeding Confusion or altered mental state Extreme fatigue or weakness These symptoms may indicate acute liver injury and require urgent assessment

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VEGF is a key regulator of angiogenesis in physiological and pathological processes, such as cancer development (Xie et al., 2019)