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These findings indicate severe volume depletion secondary to excessive sweating, which triggers neurohormonal compensatory mechanisms to maximize renal water retention via increased aquaporin expression

Importantly, it inhibits melanogenesis by suppressing the activity of tyrosinase, and oral administration of GSH in humans reduces melanin production in the skin

Astragalus membranaceus polysaccharides potentiate the growth-inhibitory activity of immune checkpoint inhibitors against pulmonary metastatic melanoma in mice

However, further in-depth research, interdisciplinary collaboration, and human studies are vital to improving quality of life, clarifying effective dosages, and optimizing bioavailability