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semaglutide is stabilized against degradation by the DPP-4 enzyme

Abbreviations MSU: Monosodium urate UA: Uric acid ROS: Reactive oxygen species NSAIDs: Non-steroidal anti-inflammatory drugs H 2 O 2 : Hydrogen peroxide Pt: Platinum Pd: Palladium POD: Peroxidase CAT: Catalase SOD: Superoxide dismutase MOFs: Metalorganic frameworks SiO 2 : Silicon dioxide PDA: Polydopamine PDA@Pt: Polydopamine-platinum K 2 PtCl 6 : Potassium chloroplatinate NaBH 4 : Sodium borohydride LPS: Lipopolysaccharides DAPI: 46-Diamidino-2-phenylindole MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide KI: Potassium iodide UVVis: Ultravioletvisible PXRD: Powder X-ray diffraction XPS: X-ray photoelectron spectroscopy TEM: Transmission electron microscope PTT: Photothermal therapy NADPH: Nicotinamide Adenine Dinucleotide Phosphate FLS: Fibroblast-like synoviocytes HUVEC: Human umbilical vein endothelial cells DAF-FM DA: 3-Amino,4-aminomethyl-2', 7'-fluorescein, diacetate DHE: Dihydroethidium DCFH-DA: 2',7'-Dichlorodihydrofluorescein diacetate RDPP: [Ru(dpp) 3 ] Cl 2 TMRE: Tetramethylrhodamine, ethyl ester GPX: Glutathione peroxidase HIF-1: Hypoxia-inducible factor-1 References Choi HK, Mount DB, Reginato AM

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ACSL4 and LPCAT3 are critical mediators of PUFA-PL synthesis, while arachidonate lipoxygenase (ALOX) is responsible for lipid peroxide synthesis (Dixon et al., 2015