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When fat is removed, the skin needs to adjust to the new contours

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The final 50-80 microliters of most vials cannot be recovered cleanly without compromising stopper integrity

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This mechanism was documented in humans in 1984 by Bowers and confirmed in multiple clinical studies (Nass et al., J Clin Endocrinol Metab 2008)

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However, many people have no side effects or only have minor side effects

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