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Increased Metabolic Activity in Prostate Carcinogenesis Pathway analysis results led to the assumption that an altered metabolic activity might be involved in prostate carcinogenesis, as the analysis detected pathways like mRNA processing, a posttranscriptional modification involving enzymatic activity, the Electron Transport Chain (ETC), and Oxidative phosphorylation that are actively involved in metabolism

Kalayc S., Demirci S., ahin F., Current Psychopharmacology , 2014 , 3 , 195

The lungs are directly exposed to tobacco smoke and air pollutants that are main sources of ROS