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During Phase 1, detoxification, toxins from car exhaust, smoke, alcohol, caffeine, dioxin, drugs, radiation, heavy metals, pesticides, and other carcinogens are partially processed by specialized proteins inside mitochondria cytochromes

On the other hand, there are research results showing that, in contrast to healthy subjects, no increases in reactive nuclear factor (NF)-kB activation, interleukin-1beta (IL-1) production, antioxidant proteins (thioredoxin [TRX], Mn-SOD, heme oxygenase1 [HO-1]), or stress-protective proteins (heat shock protein-70 [HSP-70]) occurred in the quadriceps femoris muscle when COPD patients engaged in acute exercise loading [32]