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In conclusion, this work shows, for the first time, that inflammatory and neurodegenerative peripheral biomarkers are increased in patients with PAcidemia and MMAcidemia and that treatment with LC is effective to protect against these alterations

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L-carnitine transporter and fatty acid oxidation-related L-carnitine deficiency were ruled out by normal renal excretion fraction of L-carnitine (Table 1) and by demonstration of a normal acylcarnitine profile in cultured fibroblasts incubated with palmitic acid and L-carnitine (Table S1)

Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer