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This upregulation leads to an increased expression of lipogenic genes, including sterol regulatory element-binding proteins (SREBP1c) and diacylglycerol acyltransferase-2 (DGAT2), which suggests that miR-370 provides a further point of regulation of this pathway 86

Duas revises sistemticas ( Brando et al., Porto Biomedical Journal, 2021, e Osadchiy et al., Current Sexual Health Reports, 2020 ) confirmam o padro: o Lactobacillus aparece de forma consistente associado a parmetros seminais normais, enquanto gneros como Anaerococcus se associam a pior qualidade espermtica, embora ambas reconheam que a rea ainda tem heterogeneidade metodolgica e necessita de mais estudos prospectivos de larga escala