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If the antioxidant enzymes are deficient, or if ROS are produced in excessive amounts, H2O2 may accumulate in the tissues, causing oxidative protein damage and producing more ROS

251 Preclinical studies suggest acetyl-L-carnitine may preserve brain mitochondrial function, reduce oxidative stress, inhibit inflammatory activity by microglial cells, and improve dopamine signaling in the nervous system

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doi: 10.1016/S0140-6736(05)64014-7